å¥åº·èšºæã§ãã³ã¬ã¹ãããŒã«å€ãé«ãããšãã£ãå Žåã®”ã³ã¬ã¹ãããŒã«”ãšã¯ãéåžžã¯LDLã³ã¬ã¹ãããŒã«ïŒæªçã³ã¬ã¹ãããŒã«ïŒã®ããšã§ãã
以åã¯ãç·ã³ã¬ã¹ãããŒã«å€ãé«ããšé«èè¡çïŒçŸåšã¯è質ç°åžžçïŒãšå€å®ããŠããŸããããçŸåšã¯ç·ã³ã¬ã¹ãããŒã«å€ã§ã®å€å®ã¯æ€å»ãããŸããã
LDLã³ã¬ã¹ãããŒã«ïŒæªçã³ã¬ã¹ãããŒã«ïŒãé«ãã®ã«ã¯æ§ã
ãªåå ããããŸããããã®äžã€ã«é£ã¹ç©ïŒé£åïŒããããŸãã
ã³ã¬ã¹ãããŒã«ãé«ãïŒå€ãå«ãïŒé£ã¹ç©ãæãããããšæªçã³ã¬ã¹ãããŒã«å€ãäžããå¯èœæ§ããããŸãã
ãŸããéã«æªçã³ã¬ã¹ãããŒã«å€ãäžããé£åããããŸãã
åŸã£ãŠãæªçã³ã¬ã¹ãããŒã«å€ãäžããã«ã¯ãâ ã³ã¬ã¹ãããŒã«ãé«ãïŒå€ãå«ãïŒé£ã¹ç©ãæ§ãããâ¡æªçã³ã¬ã¹ãããŒã«å€ãäžããé£åãç©æ¥µçã«æãããšããéèŠã§ãã
æªçã³ã¬ã¹ãããŒã«å€ãé«ããšã©ããªãïŒ
ã³ã¬ã¹ãããŒã«ã®åã
ã³ã¬ã¹ãããŒã«ã¯é£ã¹ç©ããæåãããã»ããäž»ãšããŠèèã§åæããã现èèã®æ§æãæ§ãã«ã¢ã³ãå¯è ç®è³ªãã«ã¢ã³ãèæ±ãªã©ã®åæã«ãªã£ãŠããŸãã
LDLã³ã¬ã¹ãããŒã«ã¯ãã³ã¬ã¹ãããŒã«ãå
šèº«ãžéã¶åœ¹å²ãæ
ã£ãŠããŸãããå¢ãããããšãšè¡ç®¡ã®å
å£ã«ã³ã¬ã¹ããïŒã«ãæ²çããåè硬åãèµ·ããåå ã«ãªããŸãã
ãããŠãåè硬åã¯å¿çæ¢å¡ãè³æ¢å¡ãçºçåå ãšãªããŸãã
æªçã³ã¬ã¹ãããŒã«å€ãé«ãçç±
æªçã³ã¬ã¹ãããŒã«å€ãé«ãçç±ã«ã€ããŠãå°é家ïŒå»åž«çïŒã§ãæ§ã èŠè§£ããããŸãããå ±éããŠããã®ã¯ä»¥äžã§ãã
â飜åèèªé žãå€ãå«ãé£åã®æå
LDLã³ã¬ã¹ãããŒã«ã®åºæºå€
LDLã³ã¬ã¹ãããŒã«ã®åºæºå€ã¯ã70ïœ139mg/dlã
åçåŽåçã®è質ç°åžžç蚺æåºæºïŒç©ºè
¹ææ¡è¡ïŒã§ã¯ãLDLã³ã¬ã¹ãããŒã«å€ã140mg/dL以äžã®å Žåã”é«LDLã³ã¬ã¹ãããŒã«è¡ç”ãšãªããŸãã
ãŸãã人éããã°åäŒã®LDLã³ã¬ã¹ãããŒã«å€å®åºåã2021幎床çãã§ã¯ãLDLã³ã¬ã¹ãããŒã«å€ã”59以äžã180以䞔ã®å Žåã”DèŠæ²»ç”ãšãªã£ãŠããŸãã
ã³ã¬ã¹ãããŒã«ãé«ãé£ã¹ç©äžèŠ§
âã³ã¬ã¹ãããŒã«ãããããå«ãŸããé£åããã«ã·ã¢/kaoã
ã³ã¬ã¹ãããŒã«ãå€ãå«ãé£ç©ãæŠåç é¢ã
â»åç
§ïŒã³ã¬ã¹ãããŒã«ãå€ãå«ãé£ç©ãæŠåç
é¢ã
ã³ã¬ã¹ãããŒã«ãããããå«ãŸããé£åããã«ã·ã¢/kaoã
ã³ã¬ã¹ãããŒã«ã¯åç©æ§é£åã«å«ãŸããŸããç¹ã«èã»éã®å
èé¡ãéåµãåµãåµã䜿ã£ãèåé¡ãªã©ã«å€ãå«ãŸããŸãã
â»åç
§ïŒã³ã¬ã¹ãããŒã«ãããããå«ãŸããé£åããã«ã·ã¢/kaoã
飜åèèªé žãå€ãé£å
LDLã³ã¬ã¹ãããŒã«ïŒæªçã³ã¬ã¹ãããŒã«ïŒãäžããé£åãšããŠçã£å
ã«æããããã®ã”ã³ã¬ã¹ãããŒã«”ãå€ãå«ãé£åã§ãã
次ã«LDLã³ã¬ã¹ãããŒã«ïŒæªçã³ã¬ã¹ãããŒã«ïŒãäžããé£åãšããŠæããããã®ãã”飜åèèªé
ž”ãå€ãå«ãé£åã§ãã
“ã³ã¬ã¹ãããŒã«”㚔飜åèèªé ž”ã®éãã¯äœã§ããããïŒ
“ã³ã¬ã¹ãããŒã«”㚔飜åèèªé ž”ã®éã
çæ°Žåç©ãããã±ã質ãè質ã¯ãäžå€§æ é€çŽ ããšåŒã°ããäœã«æ¬ ãããªãæ é€çŽ ã§ãã
è質ã«ã¯ãäžæ§èèªããªã³è質ãç³è質ãã¹ãããŒã«é¡ãªã©ããããŸãã
“飜åèèªé ž”ãšã¯ïŒ
ãŸããäžæ§èèªãæ§æããæåã§ããèèªé
žã¯ããã®æ§é ã«ãã£ãŠã飜åèèªé
žããšãäžé£œåèèªé
žãã«åé¡ãããŸãã
*äžæ§èèªã¯ãæ¥é ã¯ãšãã«ã®ãŒã®è²¯èµåº«ãšããŠèèªçµç¹ã«èããããç³è³ªã®ã¿ã§ã¯ãšãã«ã®ãŒã足ããªããšããªã©ã«ãšãã«ã®ãŒæºãšããŠäœ¿ãããŸãã
ã飜åèèªé
žãã¯æªçã³ã¬ã¹ãããŒã«å€ãäžããéã«ãäžé£œåèèªé
žãã¯æªçã³ã¬ã¹ãããŒã«å€ãäžããåãããããšèšãããŠããŸãã
“ã³ã¬ã¹ãããŒã«”ãšã¯ïŒ
“ã³ã¬ã¹ãããŒã«”ãè質ã®äžçš®ã§ãã
现èèã®ææãšãªã£ããã¹ããã€ããã«ã¢ã³ã®ææã«ãªã£ãããããªã©ãäœã«æ¬ ãããªã圹å²ãæ
ã£ãŠããŸãã
â»åç
§ïŒãè質ãªãããã³ã¬ã¹ãããŒã«ã²ãããããšã¯ã©ããªæå³ïŒâè質ã®è¡šç€ºãæ¥æ¬ã³ã«ã»ã³ãŒã©æ ªåŒäŒç€Ÿã
“ã³ã¬ã¹ãããŒã«”㚔飜åèèªé ž”ã®éã
çµè«ãšããŠã”ã³ã¬ã¹ãããŒã«”㚔飜åèèªé ž”ã¯ããããè質ã®äžçš®ã§ãããåãã«éãããããšèšããŸãã
â飜åèèªé žïŒäžæ§èèª*ã®äžçš®
*äžæ§èèªã¯ãæ¥é ã¯ãšãã«ã®ãŒã®è²¯èµåº«ãšããŠèèªçµç¹ã«èãããã
飜åèèªé žãå€ãé£å
è質ç°åžžçïŒå®è·µã»å¿çšïŒãe-ãã«ã¹ããã/åçåŽåçã
â»åç §ïŒè質ç°åžžçïŒå®è·µã»å¿çšïŒãe-ãã«ã¹ããã/åçåŽåçã
管çæ é€å£«ãæããïŒè質ç°åžžçã®é£äºã§æ°ãä»ããã¹ããã€ã³ããã¡ãã£ã«ã«ã±ã¢å ç§ã
â»åç §ïŒç®¡çæ é€å£«ãæããïŒè質ç°åžžçã®é£äºã§æ°ãä»ããã¹ããã€ã³ããã¡ãã£ã«ã«ã±ã¢å ç§ã
LDLïŒæªçïŒã³ã¬ã¹ãããŒã«ãé«ãã®æ¹ã®é£äºã®ãã€ã³ãïœã³ã¬ã¹ãããŒã«ãäžããé£åã倧接åžã
â»åç §ïŒLDLïŒæªçïŒã³ã¬ã¹ãããŒã«ãé«ãã®æ¹ã®é£äºã®ãã€ã³ãïœã³ã¬ã¹ãããŒã«ãäžããé£åã倧接åžã
ãã©ã³ã¹èèªé ž
æªçã³ã¬ã¹ãããŒã«å€ãäžããèŠå ãšããŠã³ã¬ã¹ãããŒã«åã³é£œåèèªé
žãå€ãé£åïŒé£ã¹ç©ïŒãèŠãŠããŸããã
ããã§èèªé
žã®äžçš®ã§ãããã©ã³ã¹èèªé
žã«ã€ããŠè§ŠããŸãã
ãã©ã³ã¹èèªé žãšã¯ïŒ
ãã©ã³ã¹èèªé
žã¯ãè質ã®æ§ææåã§ããèèªé
žã®äžçš®ã§ãã
æ€ç©æ²¹ãªã©ããããŒã¬ãªã³ãã·ã§ãŒããã³ã°ãªã©ã補é ããéãæ€ç©æ²¹ãé«æž©ã«ããŠè±èããå·¥çšã§çããŸãã
ãŸãã倩ç¶ã§ããçãªã©ã®åããåç©ã«ç±æ¥ãã乳補åãèã«å«ãŸããŠããŸãã
â»åç
§ïŒãã©ã³ã¹èèªé
žã«é¢ããQïŒAãåçåŽåçã
ãã©ã³ã¹èèªé žã®å®³
å¹³åçãªæ¥æ¬äººããå€ããã©ã³ã¹èèªé žæåéãåºã«ããè«žå€åœã®ç 究çµæã«ãããšããã©ã³ã¹èèªé žã®éå°æåã«ãããå¿çæ¢å¡ãªã©ã®å åèçŸæ£ãå¢å ããå¯èœæ§ãé«ããšãããŠããŸãã
ãŸããè¥æºãã¢ã¬ã«ã®ãŒæ§çŸæ£ã«ã€ããŠãé¢é£ãèªããããŠããŸãããç³å°¿ç
ããããèç³ãè³åäžãèªç¥çãªã©ã«ã€ããŠã®é¢é£ã¯åãã£ãŠããŸããã
â»åç
§ïŒåè¿°ãšåã
HDLïŒåçïŒã³ã¬ã¹ãããŒã«ãæžãããLDLïŒæªçïŒã³ã¬ã¹ãããŒã«ãå¢ããäœçšããããŸãã
ãã©ã³ã¹èèªé žãå€ãå«ãé£å
ãã©ã³ã¹èèªé žã«ã¯ã倩ç¶ã«é£åäžã«å«ãŸããŠãããã®ãšãæ²¹èãå å·¥ã»ç²Ÿè£œããå·¥çšã§ã§ãããã®ããããŸãã
倩ç¶ã«ã§ãããã®
çèãçŸèãçä¹³ã乳補åã®äžã«ã¯åŸ®éã®ãã©ã³ã¹èèªé žã倩ç¶ã«å«ãŸããŠããŸãã
æ²¹èã®å å·¥ã»ç²Ÿè£œã§ã§ãããã®
éšåçã«æ°ŽçŽ æ·»å ããæ²¹èãçšããŠäœãããããŒã¬ãªã³ããã¡ããã¹ãã¬ãããã·ã§ãŒããã³ã°ããããããåææã«äœ¿ã£ããã³ãã±ãŒããããŒãããªã©ã®æŽèåãæãç©ãªã©ã«ããã©ã³ã¹èèªé
žãå«ãŸããŠãããã®ããããŸãã
â»åç
§ïŒããã«ããããã©ã³ã¹èèªé
žã蟲ææ°Žç£çã
ãè£è¶³ããã©ã³ã¹èèªé žã¯ããã³ãèåãæãç©ãªã©ã«äœ¿ãããŠããæ€ç©æ²¹ã«å«ãŸããŠããããšãããã®ã§ãç¥ããç¥ããã®å ã«éå°æåããŠããå¯èœæ§ããããŸãã
æªçã³ã¬ã¹ãããŒã«å€ãäžããé£å
æªçã³ã¬ã¹ãããŒã«å€ãäžããé£åã«ä»¥äžã®ãã®ããããŸãã
äžé£œåèèªé žãå€ãå«ãé£å
èèªé žã®åé¡
èèªé žã¯ã飜åèèªé žãšäžé£œåèèªé žã«åé¡ãããŸãã
äžé£œåèèªé žã¯ãå€äŸ¡äžé£œåèèªé žãšäžäŸ¡äžé£œåèèªé žã«åé¡ãããããã«å€äŸ¡äžé£œåèèªé žã¯ããªã¡ã¬6ç³»ãšãªã¡ã¬3ç³»ã«åé¡ãããŸãã
å€äŸ¡äžé£œåèèªé žã®æå
âå€äŸ¡äžé£œåèèªé
ž
1æ¥ã«å€§ãã1æ¯çšåºŠã®æ€ç©æ²¹ãæçã«äœ¿ããŸãããã
ãã ãããªãªãŒãæ²¹ãããæ²¹ãªã©ã«ã¯å€äŸ¡äžé£œåèèªé
žã¯ã»ãšãã©å«ãŸããŸããã*
*ãªãªãŒãæ²¹ã«ã¯äžäŸ¡äžé£œåèèªé
žïŒãªã¬ã€ã³é
žïŒãå€ãå«ãŸããŸãã
ãªã¬ã€ã³é
žã¯ãé
žåããã«ããããšããåè硬åãå¿çŸæ£ãæãã«ããæ²¹ã®æåãšããŠç¥ãããŠããŸãã
ân-3ç³»å€äŸ¡äžé£œåèèªé
ž
EPAãDHAãšãã£ãn-3ç³»å€äŸ¡äžé£œåèèªé
žã¯ééé¡ã®èèªã«å€ãå«ãŸããŸãã
1æ¥ã«éã1åãçšåºŠãé£ã¹ãããã«ããŸãããã
â»åç
§ïŒè質ç°åžžçïŒå®è·µã»å¿çšïŒãe-ãã«ã¹ããã/åçåŽåçã
n-6ç³»å€äŸ¡äžé£œåèèªé ž
n-6ç³»ã®å€äŸ¡äžé£œåèèªé
žã¯ããªããŒã«é
žãã¢ã©ããã³é
žãªã©ããããŸãã
äž»ã«ã²ãŸããæ²¹ã倧è±æ²¹ãã³ãŒã³æ²¹ãªã©ã®æ€ç©æ§æ²¹ãªã©ã«å€ãå«ãŸããŸãã
éå°ã«æåãããšãåè硬åãåŒãèµ·ãããããæªæ§è
«çã®åå ã«ãªãå¯èœæ§ããããŸãã
â»åç
§ïŒEPAïŒã€ã³ãµãã³ãé
žïŒã«ã€ããŠã倧æ£è£œè¬ã
é£ç©ç¹ç¶ãå€ãå«ãé£å
é£ç©ç¹ç¶ãå€ãæããšäœå
ã®ã³ã¬ã¹ãããŒã«ãéããã«äœå€ãžæåºããŠãããåãããããŸãã
é£ç©ç¹ç¶ã¯ãæ€ç©æ§é£åã«å€ãå«ãŸããŠããŸãã
ç¹ã«ã氎溶æ§é£ç©ç¹ç¶ã¯LDLã³ã¬ã¹ãããŒã«ã®æåºã«å¹æããããšèšãããŠããŸãã
åçåŽåççå®ãæ¥æ¬äººã®é£äºæååºæºïŒ2020幎çïŒãã§ã¯ã1æ¥ãããã®ãç®æšéãã¯ã18ïœ64æ³ã§ç·æ§21g以äžã女æ§18g以äžãšãªã£ãŠããŸããïŒ65æ³ä»¥äžç·æ§20g以äžã女æ§17g以äžïŒ
æªçã³ã¬ã¹ãããŒã«å€ãé«ã人ã®é£äº
以äžãã³ã¬ã¹ãããŒã«ãé«ãé£ã¹ç©ã飜åèèªé žãå€ãé£åãæªçã³ã¬ã¹ãããŒã«å€ãäžããé£åãèŠãŠããŸããã
æªçã³ã¬ã¹ãããŒã«å€ãé«ã人ãé£äºã®æã«æ°ãä»ããã¹ãç¹ã¯ä»¥äžã®4ç¹ã§ãã
â飜åèèªé žãå€ãé£åãæ§ããâ飜åèèªé žãå€ãå«ãé£å
âãã©ã¹èèªé žãå«ãé£åãæ§ããâãã©ã³ã¹èèªé ž
âæªçã³ã¬ã¹ãããŒã«å€ãäžããé£åãç©æ¥µçã«æãâäžé£œåèèªé žãå€ãå«ãé£åã»é£ç©ç¹ç¶ãå€ãå«ãé£å